3-Amino-1,2-propanediol → HCID 131725719, compound

HRID 1797326Notes

Reaction equation

HRID 1797326 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:31])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])=[C:19]([Cl:32])[CH:18]=2)=[C:6]([NH:8][C:9](=[O:15])[CH2:10][CH2:11][C:12]([OH:14])=O)[CH:7]=1.[NH2:33][CH2:34][CH:35]([OH:38])[CH2:36][OH:37]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:31])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])=[C:19]([Cl:32])[CH:18]=2)=[C:6]([NH:8][C:9](=[O:15])[CH2:10][CH2:11][C:12]([NH:33][CH2:34][CH:35]([OH:38])[CH2:36][OH:37])=[O:14])[CH:7]=1

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 22174490HCID 22174490, compound

Product 1

HCID 131725719HCID 131725719, compound

Procedure

The reaction and work up was conducted as described in the preparation of compound 211. Starting compounds were N-(5-bromo-2-{[3-chloro-4-(2-methylbenzoyl)phenyl]amino}phenyl)-succinamic acid (600 mg, 1.16 mmol) (prepared as described in WO 01/05746) and 3-amino-1,2-propane-diol (117 mg, 1.28 mmol). The crude product was purified by flash chromatography using EtOAc followed by EtOAC/MeOH 95:5 as the eluent to afford the title compound as a solid.

Workup

  1. customThe reaction and work
  2. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-58e008959d744b4fa9d18676c0b39bdb
Source dataset
uspto-grants-2006_04
Patent number
US07034015B2

Reaction notes

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