Parabanic acid → HCID 22174530, Verbindung

HRID 1797333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1797333
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH2:25][O:26][CH2:27][CH2:28]O)[CH:3]=1.[C:30]1([NH:37][C:35](=[O:36])[NH:34][C:32]1=[O:33])=[O:31]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH:3]=1)[CH2:25][O:26][CH2:27][CH2:28][N:34]1[C:32](=[O:33])[C:30](=[O:31])[NH:37][C:35]1=[O:36]

Komponenten

3

Edukt 2

HCID 67126Parabanic acidHCID 10227340[4-({4-Bromo-2-[(2-hydroxyethoxy)methyl]phenyl}amino)-2-chlorophenyl](2-methylphenyl)methanone

Produkt 1

HCID 22174530HCID 22174530, Verbindung

Versuchsvorschrift

Compound 158 (47 mg, 0.1 mmol) and parabanic acid (16 mg, 0.14 mmol) were treated as described in the preparation of compound 219. Purification was done by flash chromatography (CH2Cl2/ethyl acetate 4:1) to provide the title compound, which was impure. The product was further purified by preparative TLC (CH2Cl2/ethyl acetate 20:1) to furnish the title compound as yellow oil.

Aufarbeitung

  1. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-8b5f0d860ff944248aa6200d56379d4d
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07034015B2

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