1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → HCID 22178188, compound

HRID 1797395Notes

Reaction equation

HRID 1797395 reaction equation
[OH2:1].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([CH2:27][CH2:28][CH:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32])(C(C)(C)C)(C)C>O1CCCC1>[OH:1][CH2:27][CH2:28][CH:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32]

Participants

4

Reactant 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 22178187HCID 22178187, compound2×

Product 1

HCID 22178188HCID 22178188, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

12.18 g (46.61 mmol) of tetrabutylammonium fluoride hydrate is added to a solution that consists of 3 g (11.65 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(R,S)-hydroxy-pentane-nitrile of the title compound of Example 6a, dissolved in 40 ml of tetrahydrofuran, and it is stirred for 16 hours at room temperature. Then, it is evaporated to the dry state in a vacuum. The residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient).

Workup

  1. customThen, it is evaporated to the dry state in a vacuum
  2. customThe residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient)

Sources & evidence

ORD record
ord-1c2b931331814c929128f80b76b50d6d
Source dataset
uspto-grants-2006_04
Patent number
US07034165B2

Reaction notes

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