反应详情

Concentrated hydrochloric acid (3 mL) was added to a suspension of (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid (3 g) in methanol (15 mL), and the mixture was refluxed for 4 hours. The solvent of the reaction mixture was removed by distillation under reduced pressure to give the title compound (4.0 g, yield 100%).

1. temperaturethe mixture was refluxed for 4 hours
2. customThe solvent of the reaction mixture was removed by distillation under reduced pressure