Hydrochloric Acid → HCID 22176105, compound

Participants

Reaction Steps

Tert-butyl(6-acetyl-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl)methylcarbamate (0.10 g, 0.22 mmol) was dissolved in ethyl acetate (4 mL) and a solution (1 mL) of 4N hydrogen chloride in ethyl acetate was added thereto. The mixture was stirred at room temperature for 17 h. The reaction mixture was concentrated under reduced pressure and the residue was precipitated from ethyl acetate-diisopropyl ether (1:10) to give the title compound (0.084 g, 98%) as a pale-yellow powder.

Provenance & Evidence