Hydrochloric Acid → HCID 22176105, compound

HRID 1797603Notes

Reaction equation

HRID 1797603 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:29][CH:30]([CH3:32])[CH3:31])[C:11](=[O:28])[C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:16][C:15]([C:25](=[O:27])[CH3:26])=[CH:14][CH:13]=2)(C)(C)C.[ClH:34]>C(OCC)(=O)C>[ClH:34].[C:25]([C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:28])[N:10]([CH2:29][CH:30]([CH3:31])[CH3:32])[C:9]([CH2:8][NH2:7])=[C:18]2[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)(=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22176015HCID 22176015, compound

Product 1

HCID 22176105HCID 22176105, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Tert-butyl(6-acetyl-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl)methylcarbamate (0.10 g, 0.22 mmol) was dissolved in ethyl acetate (4 mL) and a solution (1 mL) of 4N hydrogen chloride in ethyl acetate was added thereto. The mixture was stirred at room temperature for 17 h. The reaction mixture was concentrated under reduced pressure and the residue was precipitated from ethyl acetate-diisopropyl ether (1:10) to give the title compound (0.084 g, 98%) as a pale-yellow powder.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was precipitated from ethyl acetate-diisopropyl ether (1:10)

Sources & evidence

ORD record
ord-bee0d3ef54d54be1bd649d4f86c02b9e
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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