Hydrochloric Acid → HCID 22175310, compound

Participants

Reaction Steps

tert-butyl[4-butoxy-2-isobutyl-1-oxo-6-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.14 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml,) and the mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure to give 3-(aminomethyl)-4-butoxy-2-isobutyl-6-(1H-1,2,3-triazol-1-yl)-1(2H)-isoquinolinone hydrochloride (81 mg, 62.3%) as an amorphous.

Provenance & Evidence