Hydrochloric Acid → HCID 22175310, compound

HRID 1797668Notes

Reaction equation

HRID 1797668 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:11](=[O:29])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([N:24]1[CH:28]=[CH:27][N:26]=[N:25]1)=[CH:14][CH:13]=2)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[NH2:7][CH2:8][C:9]1[N:10]([CH2:30][CH:31]([CH3:32])[CH3:33])[C:11](=[O:29])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([N:24]1[CH:28]=[CH:27][N:26]=[N:25]1)=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175313HCID 22175313, compound

Product 1

HCID 22175310HCID 22175310, compoundYield 62.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-butyl[4-butoxy-2-isobutyl-1-oxo-6-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.14 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml,) and the mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure to give 3-(aminomethyl)-4-butoxy-2-isobutyl-6-(1H-1,2,3-triazol-1-yl)-1(2H)-isoquinolinone hydrochloride (81 mg, 62.3%) as an amorphous.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4431ec1550fa436d98b98d5c25314b46
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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