Hydrochloric Acid → HCID 60206217, compound

Participants

Reaction Steps

2-(3-{[(Tert-butoxycarbonyl-)amino]methyl}-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl)-4-methyl-1,3-thiazole-5-carboxylic acid (0.17 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate to give 2-[3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl-]4-methyl-1,3-thiazole-5-carboxylic acid hydrochloride (0.12 g, 92.3%) as crystals.

Provenance & Evidence