Hydrochloric Acid → HCID 60206217, compound

HRID 1797683Notes

Reaction equation

HRID 1797683 reaction equation
C(OC([NH:8][CH2:9][C:10]1[N:11]([CH2:36][CH:37]([CH3:39])[CH3:38])[C:12](=[O:35])[C:13]2[C:18]([C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:17][C:16]([C:26]1[S:27][C:28]([C:32]([OH:34])=[O:33])=[C:29]([CH3:31])[N:30]=1)=[CH:15][CH:14]=2)=O)(C)(C)C.[ClH:40]>C(OCC)(=O)C>[ClH:40].[NH2:8][CH2:9][C:10]1[N:11]([CH2:36][CH:37]([CH3:39])[CH3:38])[C:12](=[O:35])[C:13]2[C:18]([C:19]=1[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[CH:17][C:16]([C:26]1[S:27][C:28]([C:32]([OH:34])=[O:33])=[C:29]([CH3:31])[N:30]=1)=[CH:15][CH:14]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175669HCID 22175669, compound

Product 1

HCID 60206217HCID 60206217, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-(3-{[(Tert-butoxycarbonyl-)amino]methyl}-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl)-4-methyl-1,3-thiazole-5-carboxylic acid (0.17 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate to give 2-[3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl-]4-methyl-1,3-thiazole-5-carboxylic acid hydrochloride (0.12 g, 92.3%) as crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-5fd8af6624fb4000aa0f97513b9d7c2a
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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