1-(1,3-Dioxolan-2-ylmethyl)piperazine → HCID 57496168, compound

HRID 1797981Notes

Reaction equation

HRID 1797981 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:33])[NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([S:29](=[O:32])(=[O:31])[NH2:30])=[CH:25][CH:24]=3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[O:34]1[CH2:38][CH2:37][O:36][CH:35]1[CH2:39][N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1>>[O:34]1[CH2:38][CH2:37][O:36][CH:35]1[CH2:39][N:40]1[CH2:41][CH2:42][N:43]([C:1](=[NH:2])[C:3]2[CH:4]=[C:5]([NH:9][C:10](=[O:33])[NH:11][C:12]3[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][C:23]4[CH:28]=[CH:27][C:26]([S:29](=[O:31])(=[O:32])[NH2:30])=[CH:25][CH:24]=4)(=[O:20])=[O:19])=[CH:14][CH:13]=3)[CH:6]=[CH:7][CH:8]=2)[CH2:44][CH2:45]1

Participants

3

Reactant 2

HCID 27371951-(1,3-Dioxolan-2-ylmethyl)piperazineHCID 574961804-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide

Product 1

HCID 57496168HCID 57496168, compoundYield 43%

Procedure

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide following procedure C and using 2.2 equivalent of 1-(1,3-dioxolan-2-ylmethyl)piperazine as secondary amine. The product was purified by preparative HPLC.

Workup

  1. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-93294267adda4a9d85414d99e58d4eba
Source dataset
uspto-grants-2013_01
Patent number
US08343963B2

Reaction notes

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