Sodium Methoxide → HCID 12568141, compound

HRID 1798014Notes

Reaction equation

HRID 1798014 reaction equation
C([O:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10]1)(=O)C(C)(C)C.C[O-].[Na+]>CO>[OH:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 13734994HCID 13734994, compound

Product 1

HCID 12568141HCID 12568141, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(hydroxymethyl)indole is prepared by reaction of 1-(pivaloyloxy-methyl)indole with sodium methylate in methanol at ambient temperature (yield: 30%) according to the procedure described in the following publication: D. Dhanak, C. B. Reese J. Chem. Soc., Perkin Trans. 1 1986, 2181-2186. It was characterized by mass spectrometry and by 1H and 13C NMR.

Sources & evidence

ORD record
ord-f2118abcfb964f05a5b53790572b95e3
Source dataset
uspto-grants-2013_01
Patent number
US08343964B2

Reaction notes

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