反应详情

温度

35 °C

A mixture of ethyl 2-(1,6-dihydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acrylate (1 g, 3.44 mmol, 1.00 equiv, 90%) and Palladium carbon (10%, 300 mg) in ethyl acetate (50 mL) was stirred for 1 h at 35° C. under a hydrogen atmosphere. The solid was filtered out and washed with 2×10 mL of THF. The filtrate was concentrated under vacuum. This resulted in 0.8 g (71%) of ethyl 2-(1,6-dihydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)propanoate as a light-brown oil.

1. filtrationThe solid was filtered out
2. washwashed with 2×10 mL of THF
3. concentrationThe filtrate was concentrated under vacuum
4. customThis resulted in 0.8 g (71%) of ethyl 2-(1,6-dihydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)propanoate as a light-brown oil