Sodium → HCID 59323511, compound

HRID 1798469Notes

Reaction equation

HRID 1798469 reaction equation
[CH:1]1([N:4]([CH2:32][C:33]2[CH:34]=[C:35]([CH:46]=[C:47]([CH2:49][CH2:50][CH2:51][O:52][CH3:53])[CH:48]=2)[O:36][CH2:37][C@H:38]2[CH2:40][C@@H:39]2[C:41]([O:43]CC)=[O:42])[C:5]([C@@H:7]2[C@@H:12]([C:13]3[CH:14]=[N:15][C:16]([O:19][CH2:20][CH2:21][O:22][C:23]4[C:28]([Cl:29])=[CH:27][C:26]([CH3:30])=[CH:25][C:24]=4[Cl:31])=[CH:17][CH:18]=3)[CH2:11][CH2:10][NH:9][CH2:8]2)=[O:6])[CH2:3][CH2:2]1.[Na]>>[CH:1]1([N:4]([CH2:32][C:33]2[CH:34]=[C:35]([CH:46]=[C:47]([CH2:49][CH2:50][CH2:51][O:52][CH3:53])[CH:48]=2)[O:36][CH2:37][C@H:38]2[CH2:40][C@@H:39]2[C:41]([OH:43])=[O:42])[C:5]([C@@H:7]2[C@@H:12]([C:13]3[CH:14]=[N:15][C:16]([O:19][CH2:20][CH2:21][O:22][C:23]4[C:24]([Cl:31])=[CH:25][C:26]([CH3:30])=[CH:27][C:28]=4[Cl:29])=[CH:17][CH:18]=3)[CH2:11][CH2:10][NH:9][CH2:8]2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 5360545SodiumHCID 59323557HCID 59323557, compound

Product 1

HCID 59323511HCID 59323511, compound

Procedure

Prepared according to the procedure described in Example 2 but using instead ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{6-[2-(2,6-dichloro-4-methylphen-oxy)ethoxy]pyridin-3-yl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxy-propyl)phenoxy]methyl}cyclopropanecarboxylate (Example 9) as the starting material. The sodium salt of the title compound was a foam.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-44a8bb8e31e84d2993ebe1e76f0049f2
Source dataset
uspto-grants-2013_01
Patent number
US08343968B2

Reaction notes

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