Sodium → HCID 25067520, compound

HRID 1798475Notes

Reaction equation

HRID 1798475 reaction equation
[CH:1]1([N:4]([CH2:32][C:33]2[CH:34]=[C:35]([CH:45]=[C:46]([CH2:48][CH2:49][CH2:50][O:51][CH3:52])[CH:47]=2)[O:36][CH2:37][CH2:38][CH2:39][C:40]([O:42]CC)=[O:41])[C:5]([C@@H:7]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][O:22][C:23]4[C:28]([Cl:29])=[CH:27][C:26]([CH3:30])=[CH:25][C:24]=4[Cl:31])=[CH:15][CH:14]=3)[CH2:11][CH2:10][NH:9][CH2:8]2)=[O:6])[CH2:3][CH2:2]1.[Na]>>[CH:1]1([N:4]([CH2:32][C:33]2[CH:34]=[C:35]([CH:45]=[C:46]([CH2:48][CH2:49][CH2:50][O:51][CH3:52])[CH:47]=2)[O:36][CH2:37][CH2:38][CH2:39][C:40]([OH:42])=[O:41])[C:5]([C@@H:7]2[C@@H:12]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][O:22][C:23]4[C:28]([Cl:29])=[CH:27][C:26]([CH3:30])=[CH:25][C:24]=4[Cl:31])=[CH:17][CH:18]=3)[CH2:11][CH2:10][NH:9][CH2:8]2)=[O:6])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 5360545SodiumHCID 25119715HCID 25119715, compound

Product 1

HCID 25067520HCID 25067520, compound

Procedure

Prepared according to the procedure described in Example 2 but using instead ethyl 4-[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]-butanoate (Example 15) as the starting material. The sodium salt of the title compound was a foam.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-79a983b64a8d4a73a39f7f1912ce851d
Source dataset
uspto-grants-2013_01
Patent number
US08343968B2

Reaction notes

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