HRID1798491

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID61668

Boronic acid

H3BO2

结构：CC(C)Nc1cc(-c2cncc(-c3ccc(C(=O)N4CCN(C(C)C)CC4)cc3)c2)cc(-c2ccccn2)n1

HCID68732771

未命名化合物

结构：CC(C)N1CCN(C(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1

HCID68756040

未命名化合物

2 次

PRODUCTS

生成物

结构：CNc1cc(-c2cncc(-c3ccc(C(=O)N4CCNCC4)cc3)c2)cc(-c2ccccn2)n1

HCID44136481

未命名化合物

PROCEDURE

实验过程

This compound is prepared analogously to [4-(6′-Isopropylamino-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-(4-isopropyl-piperazin-1-yl)-methanone (Example 2.46) by replacing (4-Isopropyl-piperazin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone (Intermediate B4) with the appropriate boronic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5f18bfd163d54b6bb6119635054275b7
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08343966B2
来源说明: uspto-grants-2013_01

反应 SMILES

[CH:1]([NH:4][C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:8]=[C:7]([C:17]2[CH:18]=[N:19][CH:20]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([N:31]4[CH2:36][CH2:35][N:34](C(C)C)[CH2:33][CH2:32]4)=[O:30])=[CH:25][CH:24]=3)[CH:22]=2)[CH:6]=1)(C)C.C(N1CCN(C(C2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)=O)CC1)(C)C.B(O)O>>[CH3:1][NH:4][C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:8]=[C:7]([C:17]2[CH:18]=[N:19][CH:20]=[C:21]([C:23]3[CH:24]=[CH:25][C:26]([C:29]([N:31]4[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]4)=[O:30])=[CH:27][CH:28]=3)[CH:22]=2)[CH:6]=1