Boronic Acid → [4-(6'-Methylamino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-piperazin-1-yl-methanone

Participants

Role	Name	HCID	Charge
Reactant	Boronic Acid	HCID 61668	—
Reactant	[4-(6'-Isopropylamino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-(4-isopropyl-piperazin-1-yl)-methanone	HCID 68732771	—
Reactant	(4-Isopropyl-piperazin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone	HCID 68756040	—
Product	[4-(6'-Methylamino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-piperazin-1-yl-methanone	HCID 44136481	—

Reaction Steps

This compound is prepared analogously to [4-(6′-Isopropylamino-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-(4-isopropyl-piperazin-1-yl)-methanone (Example 2.46) by replacing (4-Isopropyl-piperazin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone (Intermediate B4) with the appropriate boronic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343966B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-5f18bfd163d54b6bb6119635054275b7
Source note	uspto-grants-2013_01