Boronic Acid → [4-(6'-tert-Butylamino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

HRID 1798493Notes

Reaction equation

HRID 1798493 reaction equation
[C:1]([NH:5][C:6]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH:9]=[C:8]([C:18]2[CH:19]=[N:20][CH:21]=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([N:32]4[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]4)=[O:31])=[CH:26][CH:25]=3)[CH:23]=2)[CH:7]=1)([CH3:4])([CH3:3])[CH3:2].N1(C(C2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)=O)CCNC[CH2:39]1.B(O)O>>[C:1]([NH:5][C:6]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH:9]=[C:8]([C:18]2[CH:19]=[N:20][CH:21]=[C:22]([C:24]3[CH:25]=[CH:26][C:27]([C:30]([N:32]4[CH2:37][CH2:36][N:35]([CH3:39])[CH2:34][CH2:33]4)=[O:31])=[CH:28][CH:29]=3)[CH:23]=2)[CH:7]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 177499131-(4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazineHCID 68762609[4-(6'-tert-Butylamino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-piperazin-1-yl-methanone

Product 1

HCID 68763603[4-(6'-tert-Butylamino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

Procedure

The title compound is prepared analogously to [4-(6′-tert-Butylamino-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-piperazin-1-yl-methanone (Example 2.48) by replacing piperazin-1-yl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone with the appropriate boronic acid.

Sources & evidence

ORD record
ord-acdf0299bd44494bbc0f2cb404b7b056
Source dataset
uspto-grants-2013_01
Patent number
US08343966B2

Reaction notes

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