反应详情

温度

70 °C

To a suspension of glycine hydrochloride (400 g, 3.58 mol) in n-butanol (8 L), thionyl chloride (1.37 L, 18.84 mol) was added slowly dropwise. After addition was complete, the reaction was heated at 70° C. overnight. The product mixture was concentrated under vacuum and the residue was triturated with a mixture of heptane/ethyl acetate. The white solid precipitated was filtered and dried under a stream of dry nitrogen to provide the title compound.

1. additionwas added slowly dropwise
2. additionAfter addition
3. concentrationThe product mixture was concentrated under vacuum
4. customthe residue was triturated with a mixture of heptane/ethyl acetate
5. customThe white solid precipitated
6. filtrationwas filtered
7. customdried under a stream of dry nitrogen