2-(5''-Bromo-[2,2';4',3'']terpyridin-6'-yl)-propan-2-ol → 2-[5''-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-yl]-propan-2-ol

HRID 1798503Notes

Reaction equation

HRID 1798503 reaction equation
CNC1N=C(C2C=CC=CN=2)C=C(C2C=NC=C([C:21]3[CH:22]=[N:23][N:24]([CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[CH:25]=3)C=2)C=1.Br[C:33]1[CH:34]=[C:35]([C:39]2[CH:44]=[C:43]([C:45]([OH:48])([CH3:47])[CH3:46])[N:42]=[C:41]([C:49]3[CH:54]=[CH:53][CH:52]=[CH:51][N:50]=3)[CH:40]=2)[CH:36]=[N:37][CH:38]=1>>[NH:29]1[CH2:28][CH2:27][CH:26]([N:24]2[CH:25]=[C:21]([C:33]3[CH:34]=[C:35]([C:39]4[CH:44]=[C:43]([C:45]([OH:48])([CH3:47])[CH3:46])[N:42]=[C:41]([C:49]5[CH:54]=[CH:53][CH:52]=[CH:51][N:50]=5)[CH:40]=4)[CH:36]=[N:37][CH:38]=3)[CH:22]=[N:23]2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 687351972-(5''-Bromo-[2,2';4',3'']terpyridin-6'-yl)-propan-2-olHCID 68757252Methyl-[5''-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-yl]-amine

Product 1

HCID 687616462-[5''-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-yl]-propan-2-ol

Procedure

is prepared analogously to Methyl-[5″-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[2,2′;4′,3″]terpyridin-6′-yl]-amine (Example 2.183) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-methyl-amine (Example 2.1; step 1) with 2-(5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-propan-2-ol (Example 2.80; step2)

Sources & evidence

ORD record
ord-bb132a1331bb4e80a75928e2123361ae
Source dataset
uspto-grants-2013_01
Patent number
US08343966B2

Reaction notes

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