1-Tert-butyl-4-prop-2-YN-1-ylpiperazine → {5''-[3-(4-tert-Butyl-piperazin-1-yl)-prop-1-ynyl]-[2,2';4',3'']terpyridin-6'-yl}-isopropyl-amine

Participants

Role	Name	HCID	Charge
Reactant	1-Tert-butyl-4-prop-2-YN-1-ylpiperazine	HCID 45099793	—
Reactant	1-(Prop-2-YN-1-YL)-4-(propan-2-YL)piperazine	HCID 58366557	—
Reactant	(5''-Bromo-[2,2';4',3'']terpyridin-6'-yl)-isopropyl-amine	HCID 68733072	—
Reactant	Cyclopropyl-{5''-[3-(4-isopropyl-piperazin-1-yl)-prop-1-ynyl]-[2,2';4',3'']terpyridin-6'-yl}-amine	HCID 68760033	—
Product	{5''-[3-(4-tert-Butyl-piperazin-1-yl)-prop-1-ynyl]-[2,2';4',3'']terpyridin-6'-yl}-isopropyl-amine	HCID 68761638	—

Reaction Steps

This compound is prepared analogously to Cyclopropyl-{5″-[3-(4-isopropyl-piperazin-1-yl)-prop-1-ynyl]-[2,2′;4′,3″]terpyridin-6′-yl}-amine (Example 2.127) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-cyclopropyl-amine (Example 1.26) with (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-isopropyl-amine (Example 2.46, step1) and by replacing 1-isopropyl-4-(prop-2-ynyl)piperazine (Intermediate D1) with 1-tert-Butyl-4-prop-2-ynyl-piperazine (Intermediate D2).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343966B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-fef2c4449af44f8da57a22c5f4532602
Source note	uspto-grants-2013_01