4-((4-Tert-butylpiperazin-1-yl)methyl)phenylboronic acid → 5''-[4-(4-tert-Butyl-piperazin-1-ylmethyl)-phenyl]-[2,2';4',3'']terpyridin-6'-ylamine
Reaction equation
O1CCC(N2C=C([C:12]3[CH:13]=[C:14]([C:18]4[CH:23]=[C:22]([NH2:24])[N:21]=[C:20]([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=5)[CH:19]=4)[CH:15]=[N:16][CH:17]=3)C=N2)CC1.[C:31]([N:35]1[CH2:40][CH2:39][N:38]([CH2:41][C:42]2[CH:47]=[CH:46][C:45](B(O)O)=[CH:44][CH:43]=2)[CH2:37][CH2:36]1)([CH3:34])([CH3:33])[CH3:32]>>[C:31]([N:35]1[CH2:40][CH2:39][N:38]([CH2:41][C:42]2[CH:47]=[CH:46][C:45]([C:12]3[CH:13]=[C:14]([C:18]4[CH:23]=[C:22]([NH2:24])[N:21]=[C:20]([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=5)[CH:19]=4)[CH:15]=[N:16][CH:17]=3)=[CH:44][CH:43]=2)[CH2:37][CH2:36]1)([CH3:34])([CH3:33])[CH3:32]Participants
3
Procedure
This compound is prepared analogously to 5″-[1-(Tetrahydro-pyran-4-yl)-1H-pyrazol-4-yl]-[2,2′;4′,3″]terpyridin-6′-ylamine (Example 2.156) by replacing 1-(tetrahydro-pyran-4-yl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (Intermediate B18) with 4-((4-tert-butylpiperazin-1-yl)methyl)phenylboronic acid (Intermediate B10).
Sources & evidence
- ORD record
- ord-6e632f7723234beab02a42d9ffcef66b
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08343966B2
Reaction notes
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