4-((4-Tert-butylpiperazin-1-yl)methyl)phenylboronic acid → 5''-[4-(4-tert-Butyl-piperazin-1-ylmethyl)-phenyl]-[2,2';4',3'']terpyridin-6'-ylamine

Participants

Role	Name	HCID	Charge
Reactant	4-((4-Tert-butylpiperazin-1-yl)methyl)phenylboronic acid	HCID 61532866	—
Reactant	5''-[1-(Tetrahydro-pyran-4-yl)-1H-pyrazol-4-yl]-[2,2';4',3'']terpyridin-6'-ylamine	HCID 68761382	—
Product	5''-[4-(4-tert-Butyl-piperazin-1-ylmethyl)-phenyl]-[2,2';4',3'']terpyridin-6'-ylamine	HCID 68758815	—

Reaction Steps

This compound is prepared analogously to 5″-[1-(Tetrahydro-pyran-4-yl)-1H-pyrazol-4-yl]-[2,2′;4′,3″]terpyridin-6′-ylamine (Example 2.156) by replacing 1-(tetrahydro-pyran-4-yl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (Intermediate B18) with 4-((4-tert-butylpiperazin-1-yl)methyl)phenylboronic acid (Intermediate B10).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343966B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-6e632f7723234beab02a42d9ffcef66b
Source note	uspto-grants-2013_01