1-(Prop-2-YN-1-YL)-4-(propan-2-YL)piperazine → {5''-[3-(4-Isopropyl-piperazin-1-yl)-prop-1-ynyl]-[2,2';4',3'']terpyridin-6'-yl}-methyl-amine

HRID 1798540Notes

Reaction equation

HRID 1798540 reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:6]=[C:5]([C:15]2[CH:16]=[N:17][CH:18]=[C:19]([C:21]#[C:22]C3N(C)C=NC=3)[CH:20]=2)[CH:4]=1.[CH:29]([N:32]1[CH2:37][CH2:36][N:35]([CH2:38]C#C)[CH2:34][CH2:33]1)([CH3:31])[CH3:30]>>[CH:29]([N:32]1[CH2:37][CH2:36][N:35]([CH2:38][C:22]#[C:21][C:19]2[CH:20]=[C:15]([C:5]3[CH:4]=[C:3]([NH:2][CH3:1])[N:8]=[C:7]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=4)[CH:6]=3)[CH:16]=[N:17][CH:18]=2)[CH2:34][CH2:33]1)([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 583665571-(Prop-2-YN-1-YL)-4-(propan-2-YL)piperazine2×HCID 86633650Methyl-[5''-(3-methyl-3H-imidazol-4-ylethynyl)-[2,2';4',3'']terpyridin-6'-yl]-amine

Product 1

HCID 86633652{5''-[3-(4-Isopropyl-piperazin-1-yl)-prop-1-ynyl]-[2,2';4',3'']terpyridin-6'-yl}-methyl-amine

Procedure

This compound is prepared analogously to Methyl-[5″-(3-methyl-3H-imidazol-4-ylethynyl)-[2,2′;4′,3″]terpyridin-6′-yl]-amine (Example 2.182) by replacing 1-methyl-5-((trimethylsilyl)ethynyl)-1H-imidazole with 1-isopropyl-4-(prop-2-ynyl)piperazine (Intermediate D1)

Sources & evidence

ORD record
ord-9894fb0d0ac84006be010398259c70d8
Source dataset
uspto-grants-2013_01
Patent number
US08343966B2

Reaction notes

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