3-(Trifluoromethyl)phenyl isocyanate → HCID 58941068, compound

HRID 1798728Notes

Reaction equation

HRID 1798728 reaction equation
[F:1][C:2]1[C:3]([N:14]=P(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[C:4](/[CH:8]=[CH:9]/[C:10]([O:12][CH3:13])=[O:11])[CH:5]=[CH:6][CH:7]=1.[N:34]([C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([F:46])([F:45])[F:44])[CH:38]=1)=[C:35]=O.[F:47][C:48]1[CH:56]=[CH:55][C:54]2[N:53]3[CH2:57][CH2:58][NH:59][CH2:60][C:52]3=[CH:51][C:50]=2[CH:49]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[N:14]=[C:35]([N:59]1[CH2:58][CH2:57][N:53]3[C:54]4[CH:55]=[CH:56][C:48]([F:47])=[CH:49][C:50]=4[CH:51]=[C:52]3[CH2:60]1)[N:34]([C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([F:46])([F:45])[F:44])[CH:38]=1)[CH:8]2[CH2:9][C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 3

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 11983908Methyl (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}propenoateHCID 451157698-Fluoro-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Product 1

HCID 58941068HCID 58941068, compound

Procedure

Starting with 546 mg (1.2 mmol) of the iminophosphorane from Example 12A, 402 mg (1.2 mmol) of 1-isocyanato-3-(trifluoromethyl)benzene and 240 mg (1.3 mmol) of 8-fluoro-1,2,3,4-tetrahydropyrazino[1,2-a]indole from Example 36A, the general procedure [M] gives 610 mg (86% of theory) of product.

Workup

  1. customthe general procedure [M] gives 610 mg (86% of theory) of product

Sources & evidence

ORD record
ord-83a4b1fafd154fff8251b447b60ac6c6
Source dataset
uspto-grants-2013_01
Patent number
US08343981B2

Reaction notes

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