HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → HCID 135761788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 21925255 | HCID 21925255 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 135761788 | HCID 135761788 | — |
Reaction Steps
Prepared by treating 4-[(3-chloro-4-fluoro-phenyl)amino]-6-(1-trifluoroacetyl-piperidin-4-yloxy)-7-acetoxy-quinazoline-hydrochloride with saturated sodium hydrogen carbonate solution in methanol at ambient temperature. In addition to the desired product, some 4-[(3-chloro-4-fluoro-phenyl)amino]-6-(piperidin-4-yloxy)-7-hydroxy-quinazoline is also isolated as a by-product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343982B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0e07e3456ca74d7abb7949b07d4ddeaa |
| Source note | uspto-grants-2013_01 |