Sodium Bicarbonate → HCID 135761788, compound

HRID 1798729Notes

Reaction equation

HRID 1798729 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([NH:10][C:11]2[C:20]3[C:15](=[CH:16][C:17]([O:34]C(=O)C)=[C:18]([O:21][CH:22]4[CH2:27][CH2:26][N:25]([C:28](=[O:33])[C:29]([F:32])([F:31])[F:30])[CH2:24][CH2:23]4)[CH:19]=3)[N:14]=[CH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[F:9].C(=O)([O-])O.[Na+]>CO>[Cl:2][C:3]1[CH:4]=[C:5]([NH:10][C:11]2[C:20]3[C:15](=[CH:16][C:17]([OH:34])=[C:18]([O:21][CH:22]4[CH2:27][CH2:26][N:25]([C:28](=[O:33])[C:29]([F:30])([F:31])[F:32])[CH2:24][CH2:23]4)[CH:19]=3)[N:14]=[CH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[F:9]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 21925255HCID 21925255, compound

Product 1

HCID 135761788HCID 135761788, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared by treating 4-[(3-chloro-4-fluoro-phenyl)amino]-6-(1-trifluoroacetyl-piperidin-4-yloxy)-7-acetoxy-quinazoline-hydrochloride with saturated sodium hydrogen carbonate solution in methanol at ambient temperature. In addition to the desired product, some 4-[(3-chloro-4-fluoro-phenyl)amino]-6-(piperidin-4-yloxy)-7-hydroxy-quinazoline is also isolated as a by-product.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0e07e3456ca74d7abb7949b07d4ddeaa
Source dataset
uspto-grants-2013_01
Patent number
US08343982B2

Reaction notes

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