Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxyamine hydrochloride → 4-(4-Methoxyphenyl)-1,2-oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | 2-(4-Methoxyphenyl)malondialdehyde | HCID 3849370 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(4-Methoxyphenyl)-1,2-oxazole | HCID 18523672 | — |
반응 단계
The (4-methoxyphenyl)malonaldehyde (2.5 g, 14 mmol) was heated under reflux with hydroxylamine hydrochlorid (1.46 g, 21 mmol) in ethanol (28 mL) for 2 hours. Ethanol was removed under vacuum and the residue was purified by column chromatography through a 115 gram biotage silica gel cartridge eluting with 20-50% EtOAc/hexanes to give pale oil, which solidified upon standing overnight.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08343990B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-851503766aa84406a68194a6b6600b83 |
| 출처 메모 | uspto-grants-2013_01 |