反应详情

The (4-methoxyphenyl)malonaldehyde (2.5 g, 14 mmol) was heated under reflux with hydroxylamine hydrochlorid (1.46 g, 21 mmol) in ethanol (28 mL) for 2 hours. Ethanol was removed under vacuum and the residue was purified by column chromatography through a 115 gram biotage silica gel cartridge eluting with 20-50% EtOAc/hexanes to give pale oil, which solidified upon standing overnight.

1. customEthanol was removed under vacuum
2. customthe residue was purified by column chromatography through a 115 gram biotage silica gel cartridge
3. washeluting with 20-50% EtOAc/hexanes
4. customto give pale oil, which