反应详情

2-(4-Nitrophenyl)-2H-tetrazole (200 mg, 1.05 mmol) was suspended in ethanol (1 mL). Ethyl acetate (1 mL) was added to improved solubility. The solution was degassed and purged with nitrogen 3 times before palladium on carbon (10% w/w, 223 mg, 0.2 mmol) was added. The mixture was degassed and purged with hydrogen 3 times and stirred under a hydrogen balloon for 2 hours. The reaction was diluted with acetone and passed through a plug of silica gel, which was washed thoroughly with acetone. The filtrated was concentrated to give the crude product which was used as isolated.

1. customThe solution was degassed
2. additionwas added
3. customThe mixture was degassed
4. custompurged with hydrogen 3 times
5. additionThe reaction was diluted with acetone
6. washwas washed thoroughly with acetone
7. concentrationThe filtrated was concentrated