HCID 131730134, compound → HCID 131730135, compound

HRID 1798946Notes

Reaction equation

HRID 1798946 reaction equation
[ClH:1].[Cl:2][C:3]1[N:4]=[N:5][C:6]([CH:9]2[CH2:14][CH2:13][N:12]([CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]2)=[CH:7][CH:8]=1.[CH3:18][C:19]1(B(O)O)[CH:24]=[CH:23][CH:22]=[CH:21][NH:20]1>>[ClH:2].[ClH:1].[ClH:2].[CH:15]([N:12]1[CH2:13][CH2:14][CH:9]([C:6]2[N:5]=[N:4][C:3]([C:23]3[CH:22]=[CH:21][N:20]=[C:19]([CH3:18])[CH:24]=3)=[CH:8][CH:7]=2)[CH2:10][CH2:11]1)([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 131730134HCID 131730134, compoundHCID 131730136HCID 131730136, compound

Product 1

HCID 131730135HCID 131730135, compound

Procedure

3-Chloro-6-(1-isopropylpiperidin-4-yl)pyridazine, hydrochloride (0.5 g, 1.6 mmol) and 2-methylpyridin boronic acid (0.241 g, 1.76 mmol) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as white crystals of the trihydrochloride. Yield: 164 mg (25%).

Workup

  1. customreacted in the same manner as in example 18

Sources & evidence

ORD record
ord-85ee337a57f648d8bc775ea9940346f6
Source dataset
uspto-grants-2013_01
Patent number
US08344001B2

Reaction notes

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