HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1798948Generated: October 31, 2026
Potassium Carbonate → 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine
https://huagongshe.com/reaction/1798948
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | 2-Chloro-5-(chloromethyl)pyridine | HCID 155479 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine | HCID 43421784 | — |
Reaction Steps
Isopropylpiperazine (2.3 g, 17.94 mmol), 2-chloro-5-chloromethylpyridine (3.2 g, 19.73 mmol) and K2CO3 (26.91 g, 3.713 mmol) were mixed in EtOH (50 mL) a strongly exothermic reaction. The reaction was heated further for 12 hours at 65° C. The reaction mixture was filtered and evaporated. The crude product was used without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08344001B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-0f22ffb33d324a43b8d7b507ff606544 |
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| Source note | uspto-grants-2013_01 |
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