Potassium Carbonate → 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

HRID 1798948Notes

Reaction equation

HRID 1798948 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17]Cl)=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>CCO>[Cl:10][C:11]1[N:12]=[CH:13][C:14]([CH2:17][N:7]2[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]2)=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 780131-IsopropylpiperazineHCID 1554792-Chloro-5-(chloromethyl)pyridine

Product 1

HCID 434217841-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
65 °C

Procedure

Isopropylpiperazine (2.3 g, 17.94 mmol), 2-chloro-5-chloromethylpyridine (3.2 g, 19.73 mmol) and K2CO3 (26.91 g, 3.713 mmol) were mixed in EtOH (50 mL) a strongly exothermic reaction. The reaction was heated further for 12 hours at 65° C. The reaction mixture was filtered and evaporated. The crude product was used without any further purification.

Workup

  1. customa strongly exothermic reaction
  2. filtrationThe reaction mixture was filtered
  3. customevaporated
  4. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-0f22ffb33d324a43b8d7b507ff606544
Source dataset
uspto-grants-2013_01
Patent number
US08344001B2

Reaction notes

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