反应详情

温度

65 °C

Isopropylpiperazine (2.3 g, 17.94 mmol), 2-chloro-5-chloromethylpyridine (3.2 g, 19.73 mmol) and K2CO3 (26.91 g, 3.713 mmol) were mixed in EtOH (50 mL) a strongly exothermic reaction. The reaction was heated further for 12 hours at 65° C. The reaction mixture was filtered and evaporated. The crude product was used without any further purification.

1. customa strongly exothermic reaction
2. filtrationThe reaction mixture was filtered
3. customevaporated
4. customThe crude product was used without any further purification