4-Cyanophenylboronic acid → HCID 59543425, compound

HRID 1798953Notes

Reaction equation

HRID 1798953 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]3[CH2:18][CH2:17][CH2:16]3)[CH2:11][CH2:10]2)=[N:6][CH:7]=1.[C:19]([C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)#[N:20]>>[CH:15]1([N:12]2[CH2:13][CH2:14][N:9]([CH2:8][C:5]3[N:6]=[CH:7][C:2]([C:24]4[CH:25]=[CH:26][C:21]([C:19]#[N:20])=[CH:22][CH:23]=4)=[CH:3][CH:4]=3)[CH2:10][CH2:11]2)[CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 59543436HCID 59543436, compound

Product 1

HCID 59543425HCID 59543425, compound

Procedure

1-(5-Bromopyridin-2-ylmethyl)-4-cyclobutylpiperazine (1.163, 3.75 mmol) and 4-cyanophenyl-boronic acid (0.82 g, 5.6 mmol) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as white crystals of the free amine. Yield: 467 mg (44%)

Workup

  1. customreacted in the same manner as in example 18

Sources & evidence

ORD record
ord-8a73a05b50ba4cd9b5402b34733a9445
Source dataset
uspto-grants-2013_01
Patent number
US08344001B2

Reaction notes

Loading…