4-Cyanophenylboronic acid → HCID 25127136, compound

HRID 1798954Notes

Reaction equation

HRID 1798954 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]3[CH2:18]C[CH2:16]3)[CH2:11][CH2:10]2)=[N:6][CH:7]=1.[C:19]([C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)#[N:20]>>[CH:15]([N:12]1[CH2:11][CH2:10][N:9]([CH2:8][C:5]2[N:6]=[CH:7][C:2]([C:24]3[CH:25]=[CH:26][C:21]([C:19]#[N:20])=[CH:22][CH:23]=3)=[CH:3][CH:4]=2)[CH2:14][CH2:13]1)([CH3:16])[CH3:18]

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 59543436HCID 59543436, compound

Product 1

HCID 25127136HCID 25127136, compound

Procedure

1-(5-Bromopyridin-2-ylmethyl)-4-isopropylpiperazine (1.163, 3.75 mmol) and 4-cyanophenyl-boronic acid (0.82 g, 5.6 mmol) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as white crystals of the free amine. Yield: 241 mg (20%)

Workup

  1. customreacted in the same manner as in example 18

Sources & evidence

ORD record
ord-351710f6b6e64a8492c46e511078c644
Source dataset
uspto-grants-2013_01
Patent number
US08344001B2

Reaction notes

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