4-Methoxybenzenethiol → HCID 178492785, compound

HRID 1798970Notes

Reaction equation

Cl[C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[NH2:12][C:13]1[S:14][C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([SH:28])=[CH:24][CH:23]=1.[SH:29][C:30]1[N:34]=[CH:33][NH:32][N:31]=1>>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([S:28][C:2]2[C:3]([C:9]([NH:12][C:13]3[S:14][C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=3)=[O:11])=[N:4][C:5]([S:29][C:30]3[NH:34][CH:33]=[N:32][N:31]=3)=[CH:6][CH:7]=2)=[CH:24][CH:23]=1

Participants

Reactant 4

HCID 127654-Methoxybenzenethiol

HCID 15553Clopyralid

HCID 732382-Amino-4,5-dimethyl-1,3-thiazole

HCID 178527894HCID 178527894, compound

Product 1

HCID 178492785HCID 178492785, compound

Procedure

Compound of Production Example 144 can be produced by the same method as Production Example 1, by a method according thereto, or by a combination of these and ordinary methods, with the use of 3,6-dichloro-2-pyridinecarboxylic acid, 2-amino-4,5-dimethyl-thiazole, 4-methoxy-thiophenol and 3-mercapto-1,2,4-triazole. 1HNMR (CDCl3) δ: 2.29 (3H, s), 2.33 (3H, s), 3.87 (3H, s), 6.98-7.03 (3H, m), 7.21 (1H, d, J=8.6 Hz), 7.48 (2H, d, J=8.6 Hz), 8.29 (1H, s) ESI-MS (m/e): 471 [M+H]+

Workup

customCompound of Production Example 144 can be produced by the same method as Production Example 1, by a method

Sources & evidence

ORD record: ord-a1862ccd7cee4451af99ab72b08777ac
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08344003B2

Reaction notes

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