Hydrochloric Acid → HCID 86761736, compound

Participants

Reaction Steps

This compound was prepared by adding aqueous solution of lithium hydroxide (35 mg, 0.826 mmol) to a stirred solution of Example 19 that is Ethyl 6-{2-[(E)-2-(2-[Cyclopentyloxy]-3-methoxyphenyl)vinyl]-1H-benzimidazol-1-yl}pyridazine-3-carboxylate (200 mg, 0.413 mmol) in ethanol (5 ml) and stirring the reaction mixture at room temperature for 2 h. After completion of reaction the reaction mixture was acidified with 10% HCl until pH 4 was reached and at this pH the product precipitated out as a yellow solid which was filtered, washed with diethylether and dried under vaccum to get 210 mg of off-white solid.

Provenance & Evidence