Hydrochloric Acid → HCID 86761736, compound

HRID 1799049Notes

Reaction equation

HRID 1799049 reaction equation
[OH-].[Li+].[CH:3]1([O:8][C:9]2[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[CH:11][C:10]=2/[CH:17]=[CH:18]/[C:19]2[N:23]([C:24]3[N:29]=[N:28][C:27]([C:30]([O:32]CC)=[O:31])=[CH:26][CH:25]=3)[C:22]3[CH:35]=[CH:36][CH:37]=[CH:38][C:21]=3[N:20]=2)[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl>C(O)C>[CH:3]1([O:8][C:9]2[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[CH:11][C:10]=2/[CH:17]=[CH:18]/[C:19]2[N:23]([C:24]3[N:29]=[N:28][C:27]([C:30]([OH:32])=[O:31])=[CH:26][CH:25]=3)[C:22]3[CH:35]=[CH:36][CH:37]=[CH:38][C:21]=3[N:20]=2)[CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 58477758HCID 58477758, compound

Product 1

HCID 86761736HCID 86761736, compoundYield 111.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared by adding aqueous solution of lithium hydroxide (35 mg, 0.826 mmol) to a stirred solution of Example 19 that is Ethyl 6-{2-[(E)-2-(2-[Cyclopentyloxy]-3-methoxyphenyl)vinyl]-1H-benzimidazol-1-yl}pyridazine-3-carboxylate (200 mg, 0.413 mmol) in ethanol (5 ml) and stirring the reaction mixture at room temperature for 2 h. After completion of reaction the reaction mixture was acidified with 10% HCl until pH 4 was reached and at this pH the product precipitated out as a yellow solid which was filtered, washed with diethylether and dried under vaccum to get 210 mg of off-white solid.

Workup

  1. customThis compound was prepared
  2. customAfter completion of reaction the reaction mixture
  3. customprecipitated out as a yellow solid which
  4. filtrationwas filtered
  5. washwashed with diethylether
  6. customdried under vaccum

Sources & evidence

ORD record
ord-5177cee4ef574dccb3bd2a45d008d9dc
Source dataset
uspto-grants-2013_01
Patent number
US08344010B2

Reaction notes

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