4-(2-Cyclopropylethoxy)-n-((z)-2-[4-(cyclopropyloxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide → 4-(2-Cyclopropylethoxy)-n-{1-[4-(cyclopropyloxy)benzyl]-2-[(2-hydroxyethyl)amino]-2-oxoethyl}benzamide

HRID 1799237Notes

Reaction equation

HRID 1799237 reaction equation
C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[CH:33]1([CH2:36][CH2:37][O:38][C:39]2[CH:65]=[CH:64][C:42]([C:43]([NH:45]/[C:46](/[C:58]([NH:60][CH2:61][CH2:62][OH:63])=[O:59])=[CH:47]\[C:48]3[CH:53]=[CH:52][C:51]([O:54][CH:55]4[CH2:57][CH2:56]4)=[CH:50][CH:49]=3)=[O:44])=[CH:41][CH:40]=2)[CH2:35][CH2:34]1>>[CH:33]1([CH2:36][CH2:37][O:38][C:39]2[CH:65]=[CH:64][C:42]([C:43]([NH:45][CH:46]([CH2:47][C:48]3[CH:49]=[CH:50][C:51]([O:54][CH:55]4[CH2:56][CH2:57]4)=[CH:52][CH:53]=3)[C:58]([NH:60][CH2:61][CH2:62][OH:63])=[O:59])=[O:44])=[CH:41][CH:40]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 576844914-(2-Cyclopropylethoxy)-n-((z)-2-[4-(cyclopropyloxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamideHCID 579721504-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide

Product 1

HCID 579721564-(2-Cyclopropylethoxy)-n-{1-[4-(cyclopropyloxy)benzyl]-2-[(2-hydroxyethyl)amino]-2-oxoethyl}benzamideYield 60.4%

Procedure

A reaction similar to that described in Example (1 (1e) was conducted using 4-(2-cyclopropylethoxy)-N-((Z)-2-[4-(cyclopropyloxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide (193 mg) to give 117 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-03b3f2dfa9394366a900a83fc5018850
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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