4-(2-Cyclopropylethoxy)-n-{(z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethyl)phenyl]vinyl}benzamide → 4-(2-Cyclopropylethoxy)-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethyl)benzyl]ethyl}benzamide

HRID 1799239Notes

Reaction equation

HRID 1799239 reaction equation
C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[CH:33]1([CH2:36][CH2:37][O:38][C:39]2[CH:65]=[CH:64][C:42]([C:43]([NH:45]/[C:46](/[C:58]([NH:60][CH2:61][CH2:62][OH:63])=[O:59])=[CH:47]\[C:48]3[CH:53]=[CH:52][C:51]([C:54]([F:57])([F:56])[F:55])=[CH:50][CH:49]=3)=[O:44])=[CH:41][CH:40]=2)[CH2:35][CH2:34]1>>[CH:33]1([CH2:36][CH2:37][O:38][C:39]2[CH:65]=[CH:64][C:42]([C:43]([NH:45][CH:46]([CH2:47][C:48]3[CH:49]=[CH:50][C:51]([C:54]([F:57])([F:55])[F:56])=[CH:52][CH:53]=3)[C:58]([NH:60][CH2:61][CH2:62][OH:63])=[O:59])=[O:44])=[CH:41][CH:40]=2)[CH2:34][CH2:35]1

Participants

3

Reactant 2

HCID 576845344-(2-Cyclopropylethoxy)-n-{(z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethyl)phenyl]vinyl}benzamideHCID 579721504-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide

Product 1

HCID 160410314-(2-Cyclopropylethoxy)-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethyl)benzyl]ethyl}benzamideYield 86.9%

Procedure

A reaction similar to that described in Example (1 (1e) was conducted using 4-(2-cyclopropylethoxy)-N-{(Z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethyl)phenyl]vinyl}benzamide (212 mg) to give 185 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-71c27dfd90c74f1fa58264abe457f808
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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