HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Cyclopropylethoxy)-n-{(z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethyl)phenyl]vinyl}benzamide → 4-(2-Cyclopropylethoxy)-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethyl)benzyl]ethyl}benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Cyclopropylethoxy)-n-{(z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethyl)phenyl]vinyl}benzamide | HCID 57684534 | — |
| Reactant | 4-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide | HCID 57972150 | — |
| Product | 4-(2-Cyclopropylethoxy)-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethyl)benzyl]ethyl}benzamide | HCID 16041031 | 86.9% |
Reaction Steps
A reaction similar to that described in Example (1 (1e) was conducted using 4-(2-cyclopropylethoxy)-N-{(Z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethyl)phenyl]vinyl}benzamide (212 mg) to give 185 mg of the title compound (white powder).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344029B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-71c27dfd90c74f1fa58264abe457f808 |
| Source note | uspto-grants-2013_01 |