HRID1799244

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：COc1ccc(CCOc2ccc(C(=O)N/C(=C\c3ccc(OCC(F)F)cc3)C(=O)NCCO)cc2)cc1$

HCID57684542

未命名化合物

结构：CCCc1ccc(CC(NC(=O)c2ccc(OCCC3CC3)cc2)C(=O)NCCO)cc1

HCID57972150

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CCOc2ccc(C(=O)NC(Cc3ccc(OCC(F)F)cc3)C(=O)NCCO)cc2)cc1

HCID57972146

未命名化合物

收率 72.7%

PROCEDURE

实验过程

A reaction similar to that described in Example (1 (1e) was conducted using N-((Z)-2-[4-(2,2-difluoroethoxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)-4-[2-(4-methoxyphenyl)ethoxy]benzamide (200 mg) to give 146 mg of the title compound (white powder).

WORKUP

后处理

customA reaction similar to

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0f64ea05cd6b47499873cc87af5d1f4d
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08344029B2
来源说明: uspto-grants-2013_01

反应 SMILES

C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[F:33][CH:34]([F:71])[CH2:35][O:36][C:37]1[CH:42]=[CH:41][C:40](/[CH:43]=[C:44](\[NH:51][C:52](=[O:70])[C:53]2[CH:58]=[CH:57][C:56]([O:59][CH2:60][CH2:61][C:62]3[CH:67]=[CH:66][C:65]([O:68][CH3:69])=[CH:64][CH:63]=3)=[CH:55][CH:54]=2)/[C:45]([NH:47][CH2:48][CH2:49][OH:50])=[O:46])=[CH:39][CH:38]=1>>[F:33][CH:34]([F:71])[CH2:35][O:36][C:37]1[CH:42]=[CH:41][C:40]([CH2:43][CH:44]([NH:51][C:52](=[O:70])[C:53]2[CH:58]=[CH:57][C:56]([O:59][CH2:60][CH2:61][C:62]3[CH:63]=[CH:64][C:65]([O:68][CH3:69])=[CH:66][CH:67]=3)=[CH:55][CH:54]=2)[C:45]([NH:47][CH2:48][CH2:49][OH:50])=[O:46])=[CH:39][CH:38]=1