HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-((z)-2-[4-(2,2-Difluoroethoxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)-4-[2-(4-methoxyphenyl)ethoxy]benzamide → n-{1-[4-(2,2-Difluoroethoxy)benzyl]-2-[(2-hydroxyethyl)amino]-2-oxoethyl}-4-[2-(4-methoxyphenyl)ethoxy]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-((z)-2-[4-(2,2-Difluoroethoxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)-4-[2-(4-methoxyphenyl)ethoxy]benzamide | HCID 57684542 | — |
| Reactant | 4-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide | HCID 57972150 | — |
| Product | n-{1-[4-(2,2-Difluoroethoxy)benzyl]-2-[(2-hydroxyethyl)amino]-2-oxoethyl}-4-[2-(4-methoxyphenyl)ethoxy]benzamide | HCID 57972146 | 72.7% |
Reaction Steps
A reaction similar to that described in Example (1 (1e) was conducted using N-((Z)-2-[4-(2,2-difluoroethoxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)-4-[2-(4-methoxyphenyl)ethoxy]benzamide (200 mg) to give 146 mg of the title compound (white powder).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344029B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0f64ea05cd6b47499873cc87af5d1f4d |
| Source note | uspto-grants-2013_01 |