反应详情

Methyl 4-[(2,2-difluorocyclopropyl)methoxy]benzoate (1.94 g, 8.01 mmol) prepared in Example 40 (40a) was dissolved in ethanol (24 mL), and a 2 M lithium hydroxide aqueous solution (8 mL, 16 mmol) was added thereto at room temperature. The resulting mixture was stirred at the same temperature for 18 hours. The solvents (mainly ethanol) were evaporated, and water was added to the obtained residue. Then, the resulting mixture was changed to weak acidic by adding 2 N hydrochloric acid under ice-cooling with stirring. The precipitated insoluble substance was collected by filtration, washed with water and n-hexane, and dried under reduced pressure to give 1.73 g of the title compound (white powder, yield: 95%).

1. customat room temperature
2. customThe solvents (mainly ethanol) were evaporated
3. additionwater was added to the obtained residue
4. additionby adding 2 N hydrochloric acid under ice-
5. temperaturecooling
6. stirringwith stirring
7. filtrationThe precipitated insoluble substance was collected by filtration
8. washwashed with water and n-hexane
9. customdried under reduced pressure