Tert-Butyl 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoate → 2-({4-[(2,2-Difluorocyclopropyl)methoxy]benzoyl}amino)-3-[4-(trifluoromethoxy)phenyl]propanoic acid

HRID 1799261Notes

Reaction equation

HRID 1799261 reaction equation
[NH2:1][CH:2]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)[C:3]([O:5]C(C)(C)C)=[O:4].[F:22][C:23]1([F:37])[CH2:25][CH:24]1[CH2:26][O:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[CH:30][CH:29]=1>>[F:22][C:23]1([F:37])[CH2:25][CH:24]1[CH2:26][O:27][C:28]1[CH:36]=[CH:35][C:31]([C:32]([NH:1][CH:2]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:19])([F:20])[F:21])=[CH:15][CH:16]=2)[C:3]([OH:5])=[O:4])=[O:33])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 57972097Tert-Butyl 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoateHCID 690200884-((2,2-Difluorocyclopropyl)methoxy)benzoic acid

Product 1

HCID 690173782-({4-[(2,2-Difluorocyclopropyl)methoxy]benzoyl}amino)-3-[4-(trifluoromethoxy)phenyl]propanoic acidYield 66%

Procedure

A reaction similar to that described in Example 32 (32b) was conducted using tert-butyl 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoate (366 mg, 1.20 mmol) and 4-[(2,2-difluorocyclopropyl)methoxy]benzoic acid (274 mg, 1.20 mmol) prepared in Example 40 (40b) to give 360 mg of the title compound (white powder, yield: 66%).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-23e4f20b4a864f3b86a606f17c03dfc6
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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