HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butyl 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoate → 2-({4-[(2,2-Difluorocyclopropyl)methoxy]benzoyl}amino)-3-[4-(trifluoromethoxy)phenyl]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butyl 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoate | HCID 57972097 | — |
| Reactant | 4-((2,2-Difluorocyclopropyl)methoxy)benzoic acid | HCID 69020088 | — |
| Product | 2-({4-[(2,2-Difluorocyclopropyl)methoxy]benzoyl}amino)-3-[4-(trifluoromethoxy)phenyl]propanoic acid | HCID 69017378 | 66% |
Reaction Steps
A reaction similar to that described in Example 32 (32b) was conducted using tert-butyl 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoate (366 mg, 1.20 mmol) and 4-[(2,2-difluorocyclopropyl)methoxy]benzoic acid (274 mg, 1.20 mmol) prepared in Example 40 (40b) to give 360 mg of the title compound (white powder, yield: 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344029B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-23e4f20b4a864f3b86a606f17c03dfc6 |
| Source note | uspto-grants-2013_01 |