4-(Cyclopropylmethoxy)benzoic acid → 2-({(2S)-2-{[4-(Cyclopropylmethoxy)benzoyl]amino}-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

HRID 1799269Notes

Reaction equation

HRID 1799269 reaction equation
[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH2:21])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:18]([F:20])[F:19])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[CH:23]1([CH2:26][O:27][C:28]2[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[CH:30][CH:29]=2)[CH2:25][CH2:24]1>>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH:21][C:32](=[O:33])[C:31]1[CH:30]=[CH:29][C:28]([O:27][CH2:26][CH:23]2[CH2:24][CH2:25]2)=[CH:36][CH:35]=1)[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH:18]([F:19])[F:20])=[CH:15][CH:16]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 226453014-(Cyclopropylmethoxy)benzoic acidHCID 690163652-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Product 1

HCID 690204192-({(2S)-2-{[4-(Cyclopropylmethoxy)benzoyl]amino}-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Procedure

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-(cyclopropylmethoxy)benzoic acid prepared in Example 18 (18a) to give the title compound.

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-fd65c146ed2f450f9e0bd424c0bdf72d
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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