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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1799269Generated: October 26, 2026

4-(Cyclopropylmethoxy)benzoic acid → 2-({(2S)-2-{[4-(Cyclopropylmethoxy)benzoyl]amino}-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

https://huagongshe.com/reaction/1799269

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Cyclopropylmethoxy)benzoic acidHCID 22645301—
Reactant2-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetateHCID 69016365—
Product2-({(2S)-2-{[4-(Cyclopropylmethoxy)benzoyl]amino}-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetateHCID 69020419—

Reaction Steps

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-(cyclopropylmethoxy)benzoic acid prepared in Example 18 (18a) to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08344029B2
Source datasetuspto-grants-2013_01
ORD IDord-fd65c146ed2f450f9e0bd424c0bdf72d
Source noteuspto-grants-2013_01