HRID1799275

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3673481

4-[4-(trifluoromethyl)phenoxy]benzoic Acid

C14H9F3O3

结构：CC(=O)OCCNC(=O)[C@@H](N)Cc1ccc(OC(F)(F)F)cc1

HCID69017543

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCCNC(=O)[C@H](Cc1ccc(OC(F)(F)F)cc1)NC(=O)c1ccc(Oc2ccc(C(F)(F)F)cc2)cc1

HCID86636530

未命名化合物

PROCEDURE

实验过程

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-[4-(trifluoromethyl)phenoxy]benzoic acid used in Example 41 (41a) to give the title compound.

WORKUP

后处理

customA reaction similar to

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-acb4ef0b838949ef99a5959908f8b788
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08344029B2
来源说明: uspto-grants-2013_01

反应 SMILES

[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[C@@H:9]([NH2:22])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[F:24][C:25]([F:43])([F:42])[C:26]1[CH:41]=[CH:40][C:29]([O:30][C:31]2[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][CH:32]=2)=[CH:28][CH:27]=1>>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[C@@H:9]([NH:22][C:35](=[O:36])[C:34]1[CH:38]=[CH:39][C:31]([O:30][C:29]2[CH:40]=[CH:41][C:26]([C:25]([F:24])([F:42])[F:43])=[CH:27][CH:28]=2)=[CH:32][CH:33]=1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=1)(=[O:3])[CH3:2]