4-(4-(Trifluoromethyl)phenoxy)benzoic acid → 2-{[(2S)-3-[4-(Difluoromethoxy)phenyl]-2-({4-[4-(trifluoromethyl)phenoxy]benzoyl}amino)propanoyl]amino}ethyl acetate

HRID 1799276Notes

Reaction equation

HRID 1799276 reaction equation
[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH2:21])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:18]([F:20])[F:19])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[F:23][C:24]([F:42])([F:41])[C:25]1[CH:40]=[CH:39][C:28]([O:29][C:30]2[CH:38]=[CH:37][C:33]([C:34](O)=[O:35])=[CH:32][CH:31]=2)=[CH:27][CH:26]=1>>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH:21][C:34](=[O:35])[C:33]1[CH:37]=[CH:38][C:30]([O:29][C:28]2[CH:39]=[CH:40][C:25]([C:24]([F:23])([F:41])[F:42])=[CH:26][CH:27]=2)=[CH:31][CH:32]=1)[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH:18]([F:19])[F:20])=[CH:15][CH:16]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 36734814-(4-(Trifluoromethyl)phenoxy)benzoic acidHCID 690163652-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Product 1

HCID 690182162-{[(2S)-3-[4-(Difluoromethoxy)phenyl]-2-({4-[4-(trifluoromethyl)phenoxy]benzoyl}amino)propanoyl]amino}ethyl acetate

Procedure

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-[4-(trifluoromethyl)phenoxy]benzoic acid used in Example 41 (41a) to give the title compound.

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-ad4357d60e2f4d98beba874674887205
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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